Evaluating the risk of Endocrine Disruption (ED)

With our predictive QSAR models, we provide you with tailored profiling of your chemical at an early stage to detect its ED potential and possibly find an alternative chemical.

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Profiling ED potential with QSAR models

🔹 A two-level QSAR framework

As there are many modalities leading to endocrine disruption, we propose to perform a two-level investigation

First, the evaluation of an EDC character of a compound independently of modalities (Full ED model)
Second, a deeper investigation related to a number of modalities, namely: estrogenic/androgenic/thyroid/steroidogenic (EATS) expandable to others like AhR, etc.

🔹 Our models follows the OECD principles for the validation of QSARs

a defined toxicity category
an unambiguous algorithm
a defined application domain
statistical measures of performance
a mechanistic interpretation, if possible

Getting Benefits Right Away

✔️ PROFILE THE ENDOCRINE DISRUPTING RISK

The proposed QSAR models can evaluate the EDC character of compounds globally and/or with regard to a specific mode of action

✔️ SUBSITUTE TO SAFER CHEMICALS

By idendifying structural analogues of your chemicals known to have a reduced ED potential, we support you to find safer substitute chemicals.

✔️ ANTICIPATE REGULATION CONSTRAINTS

By selecting the safest chemicals with low or no ED potential at an early stage, you secure the upcoming tightening of regulations.

A straightforward rate per model

	Prices (excluding VAT)



ED profiling with QSAR modelsRange of QSAR models : Full ED, ER, AR, TP, StG, AhR	1,000€/compd/model
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Decision making support

We provide you with a tailor-made support to add value of your Chemicals.

How does it work?

You send us the structure of your chemical(s).

We process the compound by use of its 2D structure to calculate chemical descriptors.

We profile the ED potential of your chemical(s) according to your choice of QSAR models

The chemical descriptors of the chemical are generated then used through selected QSAR models in order to assess its the ED potential

You anticipate the future regulatory constraints.

You get an in-depth report about your chemicals and its ED potential that helps you to take the best decision and select the safest chemicals to secure the market access.